-
Structural dynamics of AAA + ATPase Drg1 and mechanism of benzo-diazaborine inhibition
Our results suggest that Drg1 may function as an unfoldase that threads a substrate protein within the pre-60S particle.
2022-11-09 -
Structural mechanism of SGLT1 inhibitors
The structure also uncovers the conformational changes of hSGLT1 during transitions from outward-open to inward-open states.
2022-10-28 -
8 Å structure of the outer rings of the Xenopus laevis nuclear pore complex obtained by cryo-EM and AI
These in-depth structural features represent a great advance in understanding the assembly of NPCs.
2022-01-11 -
Structural Insights Into the High Selectivity of the Anti-Diabetic Drug Mitiglinide
The detailed structural analysis of the mitiglinide-binding site uncovers the molecular basis of its high selectivity.
2022-06-30 -
Structural insights into the mechanism of pancreatic KATP channel regulation by nucleotides
Moreover, the structures also uncover the activation mechanism of diazoxide-type KATP openers.
2022-05-19 -
Structural insights into the covalent regulation of PAPP-A activity by proMBP and STC2
Collectively, our work reveals a novel covalent exosite-competitive inhibition mechanism of PAPP-A and its regulatory effect on placental function.
2022-12-22 -
Structure and dynamics of the EGFR/HER2 heterodimer
Together, this work deepens our understanding of the unique structural properties and dynamics of the EGFR/HER2 complex.
2023-02-13 -
The Protein Fusion Strategy Facilitates the Structure Determination of Small Membrane Proteins by Cryo-EM
This Perspective enumerates recent exemplary progress and discusses the future potential of the protein fusion strategy.
2022-08-01 -
The inhibition mechanism of the SUR2A-containing KATP channel by a regulatory helix
The structures of SUR2B in similar conditions suggest that the C-terminal 42 residues of SUR2B enhance the structural dynamics of NBD2 and facilitate the dissociation of the R helix and the binding of Mg-ADP to NBD2, promoting NBD dimerization and subsequent channel activation.
2023-06-17 -
Structure and mechanism of a neuropeptide-activated channel in the ENaC/DEG superfamily
Such conformational changes are propagated downward toward the TMD via the palm domain, possibly resulting in outward movement of the TMD and dilation of the ion conduction pore.
2023-08-07 -
Human antibody BD-218 has broad neutralizing activity against concerning variants of SARS-CoV-2
We concluded that BD-218 is a highly effective and broadly active nAb against SARS-CoV-2 variants with promising potential for therapeutic development.
2023-02-01 -
HIV-1 Env trimers asymmetrically engage CD4 receptors in membranes
Our data indicate that asymmetric HIV-1 Env trimers bound to one and two CD4 molecules are detectable intermediates during virus binding to host cell membranes, which probably has consequences for antibody-mediated immune responses and vaccine immunogen design.
2023-11-22 -
Structural insights into the assembly and mechanism of mpox virus DNA polymerase complex F8-A22-E4-H5
These structures provide snapshots for the working cycle of the polymerase and generate insights into the mechanisms of these essential factors in viral DNA replication.
2023-12-07 -
Structure, function and pharmacology of human itch receptor complexes
Collectively, our results provide a structural basis for the sensing of cationic allergens by MRGPRX2, potentially facilitating the rational design of therapies to prevent unwanted pseudoallergic reactions.
2021-11-17 -
Identification of Integrator-PP2A complex (INTAC), an RNA polymerase II phosphatase
This study provides a direct connection between PP2A-mediated dephosphorylation and transcriptional regulation, two fundamental cellular processes.
2020-11-27 -
Structural insights into immunoglobulin M
These results provide a structural basis for the function of IgM.
2020-02-06 -
The NAD+-mediated self-inhibition mechanism of pro-neurodegenerative SARM1
These findings suggest that NAD+ mediates self-inhibition of this central pro-neurodegenerative protein.
2020-10-14 -
Structurally Resolved SARS-CoV-2 Antibody Shows High Efficacy in Severely Infected Hamsters and Provides a Potent Cocktail Pairing Strategy
Together, our results rationalized a new RBD epitope that leads to high neutralization potency and demonstrated BD-368-2’s therapeutic potential in treating COVID-19.
2020-11-12 -
Potent Neutralizing Antibodies against SARS-CoV-2 Identified by High-Throughput Single-Cell Sequencing of Convalescent Patients’ B Cells
Altogether, we showed that human neutralizing antibodies could be efficiently discovered by high-throughput single B cell sequencing in response to pandemic infectious diseases.
2020-07-09 -
Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome
These data suggest that NEK7 bridges adjacent NLRP3 subunits with bipartite interactions to mediate the activation of the NLRP3 inflammasome.
2019-06-12