The structure also uncovers the conformational changes of hSGLT1 during transitions from outward-open to inward-open states.
2022-10-28These in-depth structural features represent a great advance in understanding the assembly of NPCs.
2022-01-11The detailed structural analysis of the mitiglinide-binding site uncovers the molecular basis of its high selectivity.
2022-06-30Moreover, the structures also uncover the activation mechanism of diazoxide-type KATP openers.
2022-05-19Collectively, our work reveals a novel covalent exosite-competitive inhibition mechanism of PAPP-A and its regulatory effect on placental function.
2022-12-22Together, this work deepens our understanding of the unique structural properties and dynamics of the EGFR/HER2 complex.
2023-02-13This Perspective enumerates recent exemplary progress and discusses the future potential of the protein fusion strategy.
2022-08-01The structures of SUR2B in similar conditions suggest that the C-terminal 42 residues of SUR2B enhance the structural dynamics of NBD2 and facilitate the dissociation of the R helix and the binding of Mg-ADP to NBD2, promoting NBD dimerization and subsequent channel activation.
2023-06-17Such conformational changes are propagated downward toward the TMD via the palm domain, possibly resulting in outward movement of the TMD and dilation of the ion conduction pore.
2023-08-07We concluded that BD-218 is a highly effective and broadly active nAb against SARS-CoV-2 variants with promising potential for therapeutic development.
2023-02-01Our data indicate that asymmetric HIV-1 Env trimers bound to one and two CD4 molecules are detectable intermediates during virus binding to host cell membranes, which probably has consequences for antibody-mediated immune responses and vaccine immunogen design.
2023-11-22These structures provide snapshots for the working cycle of the polymerase and generate insights into the mechanisms of these essential factors in viral DNA replication.
2023-12-07Collectively, our results provide a structural basis for the sensing of cationic allergens by MRGPRX2, potentially facilitating the rational design of therapies to prevent unwanted pseudoallergic reactions.
2021-11-17This study provides a direct connection between PP2A-mediated dephosphorylation and transcriptional regulation, two fundamental cellular processes.
2020-11-27These results provide a structural basis for the function of IgM.
2020-02-06These findings suggest that NAD+ mediates self-inhibition of this central pro-neurodegenerative protein.
2020-10-14Together, our results rationalized a new RBD epitope that leads to high neutralization potency and demonstrated BD-368-2’s therapeutic potential in treating COVID-19.
2020-11-12Altogether, we showed that human neutralizing antibodies could be efficiently discovered by high-throughput single B cell sequencing in response to pandemic infectious diseases.
2020-07-09These data suggest that NEK7 bridges adjacent NLRP3 subunits with bipartite interactions to mediate the activation of the NLRP3 inflammasome.
2019-06-12Our findings shed light on RSC assembly and functionality, and they provide a framework to understand the mammalian homologs BAF/PBAF and the Sfh1 ortholog INI1/BAF47, which are frequently mutated in cancers.
2019-10-31