These results provide insights into the detailed mechanisms regulating the autoinhibition of human ORC and its subsequent activation for DNA binding.
2020-11-24Our results pave the way for future mechanistic study and rational drug design targeting hSOAT1 and other mammalian MBOAT family members.
2020-05-18A third model proposed that a central cavity between TMs 3, 5, and 6 could accommodate the head groups of phospholipids during transporting across the membranes
2020-04-17Particularly, PANX1 undergoes a stepwise, quantized activation progress upon sequentially cleaving the C-terminal of each subunit.6
2020-04-03Moreover, mutations associated with human diseases map to the domain-domain interfaces or the pore domain of NALCN, intuitively suggesting their pathological mechanisms.
2020-12-03These data facilitate our understanding of the global conservation of ribosome assembly in eukaryotes and species-specific features of human assembly factors.
2020-07-15However, it remains unclear how the A53T mutation may alter the fibril structure and exacerbate α-syn pathology.
2020-03-12These defects amplify during synthesis of the full-length proteins and cause overall defect in protein synthesis. In conclusion, our data reveal the molecular roles of U2552 methylation in both ribosome biogenesis and protein translation.
2020-06-22These results advance the molecular understanding of SIgA and shed light on S. pneumoniae pathogenesis.
2020-05-12Our data reveal that uL4 and Nog1 work together in the maturation of ribosomal RNA helix 74, which is required to ensure proper construction of the NPET and 60S ribosomal subunits.
2020-10-09Several cryo-EM structures of the pancreatic KATP channel determined recently have provided remarkable structural insights into these two mechanisms.
2019-09-30These data establish definitively a clear example of evolutionary optimization of protein function.
2020-05-15Our structures reveal that only one insulin or one IGF-1 molecule binds to and activates the full-length human IGF-1R receptor.
2020-05-05Our work provides a structural view to the severe pathology of the PD familial mutation E46K of α-syn and highlights the importance of electrostatic interactions in defining the fibril polymorphs.
2020-05-26Together, these results suggest that the deployment of RBD-vaccines, through a third-dose boost, may be ideal for combating SARS-CoV-2 variants when necessary, especially for those carrying mutations that disrupt the NTD supersite.
2021-05-21As this substitution also leads to an alteration in the electrostatic property of RBD, it may function as an escaping mutation to diminish the potency of some neutralizing antibodies as well.
2021-08-25Overall, our results provide a model for the formation of the MCM8/9 complex and provide a path for further studies.
2021-10-07These structures suggest a converged mechanism of sGC activation by pharmacological compounds.
2021-09-17These results pave the way for further design and optimization of inhibitors targeting human TRPC5.
2021-03-08Our results provide direct evidence of how PVC cargoes are loaded and delivered directly into mammalian macrophages.
2021-06-25