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Structural and functional insights into the tetrameric photosystem I from heterocyst-forming cyanobacteria
Our physiological data also revealed a functional link of photosystem I oligomerization to cyclic electron flow and thylakoid membrane organization.
2019-10-08 -
Structural insight into the assembly and conformational activation of human origin recognition complex
These results provide insights into the detailed mechanisms regulating the autoinhibition of human ORC and its subsequent activation for DNA binding.
2020-11-24 -
Structural insights into the inhibition mechanism of human sterol O-acyltransferase 1 by a competitive inhibitor
Our results pave the way for future mechanistic study and rational drug design targeting hSOAT1 and other mammalian MBOAT family members.
2020-05-18 -
Structures of a P4-ATPase lipid flippase in lipid bilayers
A third model proposed that a central cavity between TMs 3, 5, and 6 could accommodate the head groups of phospholipids during transporting across the membranes
2020-04-17 -
Cryo-EM structures of human pannexin 1 channel
Particularly, PANX1 undergoes a stepwise, quantized activation progress upon sequentially cleaving the C-terminal of each subunit.6
2020-04-03 -
Structure of voltage-modulated sodium-selective NALCN-FAM155A channel complex
Moreover, mutations associated with human diseases map to the domain-domain interfaces or the pore domain of NALCN, intuitively suggesting their pathological mechanisms.
2020-12-03 -
Structural snapshots of human pre-60S ribosomal particles before and after nuclear export
These data facilitate our understanding of the global conservation of ribosome assembly in eukaryotes and species-specific features of human assembly factors.
2020-07-15 -
Cryo-EM structure of full-length α-synuclein amyloid fibril with Parkinson’s disease familial A53T mutation
However, it remains unclear how the A53T mutation may alter the fibril structure and exacerbate α-syn pathology.
2020-03-12 -
Loss of a single methylation in 23S rRNA delays 50S assembly at multiple late stages and impairs translation initiation and elongation
These defects amplify during synthesis of the full-length proteins and cause overall defect in protein synthesis. In conclusion, our data reveal the molecular roles of U2552 methylation in both ribosome biogenesis and protein translation.
2020-06-22 -
Structural insights into secretory immunoglobulin A and its interaction with a pneumococcal adhesin
These results advance the molecular understanding of SIgA and shed light on S. pneumoniae pathogenesis.
2020-05-12 -
Structural insights into assembly of the ribosomal nascent polypeptide exit tunnel
Our data reveal that uL4 and Nog1 work together in the maturation of ribosomal RNA helix 74, which is required to ensure proper construction of the NPET and 60S ribosomal subunits.
2020-10-09 -
Structural Insights into the Inhibitory Mechanism of Insulin Secretagogues on the Pancreatic ATP-Sensitive Potassium Channel
Several cryo-EM structures of the pancreatic KATP channel determined recently have provided remarkable structural insights into these two mechanisms.
2019-09-30 -
Cooperative transport mechanism of human monocarboxylate transporter 2
These data establish definitively a clear example of evolutionary optimization of protein function.
2020-05-15 -
Visualization of Ligand-Bound Ectodomain Assembly in the Full-Length Human IGF-1 Receptor by Cryo-EM Single-Particle Analysis
Our structures reveal that only one insulin or one IGF-1 molecule binds to and activates the full-length human IGF-1R receptor.
2020-05-05 -
Parkinson’s disease associated mutation E46K of α-synuclein triggers the formation of a distinct fibril structure
Our work provides a structural view to the severe pathology of the PD familial mutation E46K of α-syn and highlights the importance of electrostatic interactions in defining the fibril polymorphs.
2020-05-26 -
Humoral immune response to circulating SARS-CoV-2 variants elicited by inactivated and RBD-subunit vaccines. Cell Research
Together, these results suggest that the deployment of RBD-vaccines, through a third-dose boost, may be ideal for combating SARS-CoV-2 variants when necessary, especially for those carrying mutations that disrupt the NTD supersite.
2021-05-21 -
Structures of SARS-CoV-2 B.1.351 neutralizing antibodies provide insights into cocktail design against concerning variants
As this substitution also leads to an alteration in the electrostatic property of RBD, it may function as an escaping mutation to diminish the potency of some neutralizing antibodies as well.
2021-08-25 -
Structural study of the N-terminal domain of human MCM8/9 complex
Overall, our results provide a model for the formation of the MCM8/9 complex and provide a path for further studies.
2021-10-07 -
Activation mechanism of human soluble guanylate cyclase by stimulators and activators
These structures suggest a converged mechanism of sGC activation by pharmacological compounds.
2021-09-17 -
Structural basis for human TRPC5 channel inhibition by two distinct inhibitors
These results pave the way for further design and optimization of inhibitors targeting human TRPC5.
2021-03-08