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Structure of the RSC complex bound to the nucleosome
Our findings shed light on RSC assembly and functionality, and they provide a framework to understand the mammalian homologs BAF/PBAF and the Sfh1 ortholog INI1/BAF47, which are frequently mutated in cancers.
2019-10-31 -
Structural insights into the mechanism of human soluble guanylate cyclase
The resulting movement of the N termini of the catalytic domains drives structural changes within the catalytic module, which in turn boost the enzymatic activity of sGC.
2019-09-12 -
Cryo-EM Structure and Assembly of an Extracellular Contractile Injection System
Our results on the PVC provide a framework for understanding the general mechanism of widespread CISs and pave the way for using them as delivery tools in biological or therapeutic applications.
2019-04-04 -
Structural basis of assembly of the human T cell receptor–CD3 complex
Together, our data reveal the structural basis for TCR–CD3 complex assembly, providing clues to TCR triggering and a foundation for rational design of immunotherapies that target the complex.
2019-08-28 -
Structural basis of membrane skeleton organization in red blood cells
This work serves as a structural framework for understanding the assembly and dynamics of membrane skeleton and offers insights into mechanisms of various ubiquitous F-actin-binding factors in other F-actin systems.
2023-04-27 -
Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome
Synchronization of ATP binding, ADP release and ATP hydrolysis in three adjacent ATPases drives rigid-body rotations of substrate-bound ATPases that are propagated unidirectionally in the ATPase ring and unfold the substrate.
2018-09-12 -
Structure of the origin recognition complex bound to DNA replication origin
This work pinpoints a conserved role of ORC in modulating DNA structure to facilitate origin selection and helicase loading in eukaryotes.
2018-07-04 -
Structure of a Pancreatic ATP-Sensitive Potassium Channel
These structural observations suggest a molecular mechanism for KATP regulation by anti-diabetic sulfonylurea drugs, intracellular adenosine nucleotide concentrations, and PIP2 lipid.
2017-01-12 -
Structural insights into the membrane microdomain organization by SPFH family proteins
These observations provide a mechanistic explanation for the role of HflK/C and their mitochondrial homologs prohibitins in regulating membrane-bound AAA+ proteases, and suggest a general model for the organization and functionalization of membrane microdomains by SPFH proteins.
2022-01-03 -
Conformational changes of a phosphatidylcholine flippase in lipid membranes
Dnf1 may have altered conformational preferences in membranes with different lipid compositions.
2022-03-15 -
Structural remodeling of ribosome associated Hsp40-Hsp70 chaperones during co-translational folding
Altogether, in accordance with previous data, our work suggests a sequence of structural remodeling events for RAC-Ssb during co-translational folding, triggered by the binding and passage of growing nascent chain from one to another.
2022-06-14 -
A transformation clustering algorithm and its application in polyribosomes structural profiling
Our results suggest a model where polysomes are formed by connecting multiple nonstochastic blocks, in which translation is likely synchronized.
2022-07-11 -
Specificity of TGF-β1 signal designated by LRRC33 and integrin αVβ8
Together, our findings provide important insights into the specificity of TGF-β1 signaling achieved by LRRC33 and integrin αVβ8.
2022-08-25 -
Structure and dynamics of the EGFR/HER2 heterodimer
Together, this work deepens our understanding of the unique structural properties and dynamics of the EGFR/HER2 complex.
2023-02-13 -
Structural basis of SecA-mediated protein translocation
The movements of the polypeptide substrates in the SecA–SecY translocon share a similar structural basis to those in the ribosome–SecY complex during cotranslational translocation.
2023-01-04 -
Molecular mechanism of substrate recognition by folate transporter SLC19A1
Together, this work establishes the molecular basis of substrate recognition by this central folate transporter.
2022-12-28 -
Comprehensive structural characterization of the human AAA+ disaggregase CLPB in the apo- and substrate-bound states reveals a unique mode of action driven by oligomerization
These results reveal unique properties of CLPB as a general disaggregase in mitochondria and highlight its potential as a target for the treatment of various mitochondria-related diseases.
2023-02-06 -
BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection
Together, our results indicate that Omicron may evolve mutations to evade the humoral immunity elicited by BA.1 infection, suggesting that BA.1-derived vaccine boosters may not achieve broad-spectrum protection against new Omicron variants.
2022-06-17 -
Cryo-Electron Tomography of Toxoplasma gondii Indicates That the Conoid Fiber May Be Derived from Microtubules
This work represents the detailed molecular anatomy of T. gondii, particularly during the budding replication stage of tachyzoite, and provides a reference for further studies of this fascinating organism.
2023-02-25 -
Immunoglobulin M perception by FcμR
These results reveal intricate mechanisms of IgM perception by FcμR.
2023-03-22