In the presence of calcium ions, intracellular EF-hand modules might enhance the catalytic activity of DUOX by stabilizing the dehydrogenase domain in a conformation that allows electron transfer.
2021-01-08Collectively, our results provide a structural basis for the sensing of cationic allergens by MRGPRX2, potentially facilitating the rational design of therapies to prevent unwanted pseudoallergic reactions.
2021-11-17Our study reveals mechanisms of TSC complex assembly and GAP activity.
2021-01-12Selective pressure to maintain flexibility in the precursor of functional Env allows the uncleaved Env to sample asymmetric conformations that potentially skew host antibody responses toward pNAbs.
2021-11-23To address some of the fundamental questions in the field, we determined the electron cryo-microscopy (cryo-EM) structure of the endogenous TIM22 complex from S. cerevisiae.
2020-09-11Paused or collided ribosomes are associated with specific chaperones, which can aid in the cotranslational folding of the nascent peptides.
2021-01-05These results provide insights into the organization of chromophores and the mechanisms of EET within cyanobacterial PBS.
2021-09-17We conclude that GMPPA acts as a cellular sensor to maintain mannose homeostasis through allosterically regulating GMPPB.
2021-05-13SA55+SA58 potently neutralizes ACE2-utilizing sarbecoviruses, including circulating Omicron variants, and could serve as broad SARS-CoV-2 prophylactics to offer long-term protection, especially for individuals who are immunocompromised or with high-risk comorbidities.
2020-12-20Our results inform the development of antibody-based drugs and vaccines against Omicron and future variants.
2021-12-23This study elucidates the versatility of Dbf4 in regulating the ordered multisite phosphorylation of the MCM-DH by Cdc7 kinase during helicase activation.
2022-03-16These KATP openers synergize with Mg-nucleotides to stabilize SUR2 in the NBD-dimerized occluded state to activate the channel.
2022-05-13These results provide important insights into GlcNAc-1-phosphotransferase function and related diseases.
2022-03-15Furthermore, structures of human TRPC6 in complex with two chemically distinct inhibitors bound at different ligand-binding pockets reveal different conformations of the transmembrane domain, providing templates for further structure-based drug design targeting TRPC6-related diseases such as FSGS.
2022-03-16In contrast, recombinantly expressed Jupiter microtubule-associated homolog 2 (JPT2) and SM-like protein LSM12, two proteins previously identified as NAADP-receptors, show no binding in ITC experiments.
2022-07-13Our work defines the structural mechanism of NALCN modulation by UNC79 and UNC80.
2022-05-12In conclusion, it is shown that SgII is a unique intravesicular matrix protein undergoing liquid–liquid phase separation, and present novel insights into how SgII determines LDCV size and the quantal neurotransmitter release.
2022-07-27Structural analysis suggests that the cytosolic factors might activate the NOX2-p22 complex by stabilizing the DH in a productive docked conformation.
2023-12-18The mutations at the ACE2-RBD interface enhance the tight binding by increasing hydrogen bonding interaction and enlarging buried solvent accessible surface area.
2022-01-29Our results suggest that Drg1 may function as an unfoldase that threads a substrate protein within the pre-60S particle.
2022-11-09