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CD5L associates with IgM via the J chain
These results offer a more comprehensive understanding of IgM and shed light on the function of the J chain in the immune system.
2024-09-27 -
Structural insights into the high-affinity IgE receptor FcεRI complex
These findings deepen our understanding of the signalling mechanisms of FcεRI and offer insights into the functionality of other immune receptors dependent on FcRγ.
2024-08-21 -
A conserved N-terminal motif of CUL3 contributes to assembly and E3 ligase activity of CRL3KLHL22
These findings demonstrate that a CUL3 N-terminal motif participates in the assembly process and provide insights into the assembly and activation of CRL3s.
2024-05-06 -
Structural insights into VAChT neurotransmitter recognition and inhibition
Overall, our work provides a structural framework for clarifying how VAChT recognizes its substrates and inhibitors.
2024-06-11 -
Architecture and activation of human muscle phosphorylase kinase
These results provide molecular insights of this important kinase complex.
2024-03-28 -
Determining subunit-subunit interaction from statistics of cryo-EM images: observation of nearest-neighbor coupling in a circadian clock protein complex
Our results show that a KaiC hexamer can respond in a switch-like manner to changes in its phosphorylation level.
2023-09-22 -
Substrate and drug recognition mechanisms of SLC19A3
In summary, our work provides a structural framework for understanding the substrate diversity of SLC19A3.
2024-03-19 -
Parental histone transfer caught at the replication fork
Our findings offer crucial structural insights into the mechanism of replication-coupled histone recycling for maintaining epigenetic inheritance.
2024-03-06 -
Structure of human phagocyte NADPH oxidase in the activated state
These structural rearrangements might facilitate the efficient transfer of electrons between the redox centres in NOX2 and lead to the activation of phagocyte NADPH oxidase.
2024-02-14 -
Vimentin regulates nuclear segmentation in neutrophils
These results have uncovered a new component establishing the nuclear segmentation of granulocytes.
2023-11-20 -
Cryo-EM structure of human mitochondrial trifunctional protein
Our results provide the structural basis for TFP function and have important implications for fatty acid oxidation related diseases.
2018-06-18 -
Structure of the receptor-activated human TRPC6 and TRPC3 ion channels
Our structures uncover the molecular architecture of TRPC channels and provide a structural basis for understanding the mechanism of these channels.
2018-04-26 -
Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels
These structures depict the binding site of the antidiabetic drug glibenclamide, indicate how Kir6.2 (inward-rectifying potassium channel 6.2) N-terminus participates in the coupling between the peripheral SUR1 (sulfonylurea receptor 1) subunit and the central Kir6.2 channel, reveal the binding mode of activating nucleotides, and suggest the mechanism of how Mg-ADP binding on nucleotide binding domains (NBDs) drives a conformational change of the SUR1 subunit.
2018-03-28 -
Structure of the mechanosensitive OSCA channels
Our structural analysis accompanied with electrophysiological studies identifies the ion permeation pathway within each subunit and suggests a conformational change model for activation.
2018-09-06 -
Structural mechanism for nucleotide-driven remodeling of the AAA-ATPase unfoldase in the activated human 26S proteasome
These findings demonstrate an elegant mechanism of allosteric coordination among sub-machines within the human proteasome holoenzyme.
2018-04-10 -
The Structural Basis for the Binding of Repaglinide to the Pancreatic KATP Channel
Furthermore, the high-resolution structure reveals the complex architecture of the ATP binding site, which is formed by both Kir6.2 and SUR1 subunits, and the domain-domain interaction interfaces.
2019-05-07 -
An anti-CRISPR protein disables type V Cas12a by acetylation
Our study reveals an unprecedented mechanism of CRISPR–Cas inhibition and suggests an evolutionary arms race between phages and bacteria.
2019-04-01 -
Structure of the substrate-engaged SecA-SecY protein translocation machine
Taking into account previous biochemical and biophysical data, our structure is consistent with a model in which the two-helix finger and clamp cooperate during the ATPase cycle to move a polypeptide through the channel.
2019-06-28 -
hCINAP regulates the DNA-damage response and mediates the resistance of acute myelocytic leukemia cells to therapy
These results provide mechanistic insight into the function of hCINAP during the DNA-damage response and its role in AML resistance to therapy.
2019-08-23 -
Structures of the ISWI–nucleosome complex reveal a conserved mechanism of chromatin remodeling
Together, our findings suggest a general mechanism of chromatin remodeling involving local DNA distortion without notable histone deformation.
2019-03-14