These structures fill a gap in our understanding of the structural mechanisms of SGLT transporters.
2023-05-22ATP binds in the same cavity and induces conformational changes in TM2, together with the inward bending of TM1, TM4, TM5 and TM6 of UCP1, resulting in a more compact structure of UCP1.
2023-06-19This pipeline enables the determination of the properties of insulin crystals in situ for the first time, using unperturbed samples.
2023-01-19Our findings reveal the molecular basis for the DI-induced modification on the structural dynamics of the nucleosome and elucidate how the DNA glycosylase AAG accesses damaged sites on the nucleosome with different solution accessibility.
2023-06-20The bilin 1Iβ822 located near photosystem I has an enhanced planarity and is the red-bilin responsible for the direct energy transfer to photosystem I.
2023-07-05Overall, our data reveal that nuclear assembly of human pre-60S particles is generally hierarchical with short branch pathways, and a few factors display specific roles as rRNA chaperones by confining rRNA helices locally to facilitate their folding, such as the C-terminal domain of SDAD1.
2023-07-25These findings reveal an unexpected pre-sequence pathway through the TOM–TIM23 supercomplex spanning the double membranes of mitochondria.
2023-06-23