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Structures of human SGLT in the occluded state reveal conformational changes during sugar transport
These structures fill a gap in our understanding of the structural mechanisms of SGLT transporters.
2023-05-22 -
Structural basis for the binding of DNP and purine nucleotides onto UCP1
ATP binds in the same cavity and induces conformational changes in TM2, together with the inward bending of TM1, TM4, TM5 and TM6 of UCP1, resulting in a more compact structure of UCP1.
2023-06-19 -
A practical multicellular sample preparation pipeline broadens the application of in situ cryo-electron tomography
This pipeline enables the determination of the properties of insulin crystals in situ for the first time, using unperturbed samples.
2023-01-19 -
Structural and mechanistic insights into the DNA glycosylase AAG-mediated base excision in nucleosome
Our findings reveal the molecular basis for the DI-induced modification on the structural dynamics of the nucleosome and elucidate how the DNA glycosylase AAG accesses damaged sites on the nucleosome with different solution accessibility.
2023-06-20 -
Cryo-EM and femtosecond spectroscopic studies provide mechanistic insight into the energy transfer in CpcL-phycobilisomes
The bilin 1Iβ822 located near photosystem I has an enhanced planarity and is the red-bilin responsible for the direct energy transfer to photosystem I.
2023-07-05 -
Visualizing the nucleoplasmic maturation of human pre-60S ribosomal particles
Overall, our data reveal that nuclear assembly of human pre-60S particles is generally hierarchical with short branch pathways, and a few factors display specific roles as rRNA chaperones by confining rRNA helices locally to facilitate their folding, such as the C-terminal domain of SDAD1.
2023-07-25 -
Molecular pathway of mitochondrial preprotein import through the TOM–TIM23 supercomplex
These findings reveal an unexpected pre-sequence pathway through the TOM–TIM23 supercomplex spanning the double membranes of mitochondria.
2023-06-23